When you hover over an option such as “Disable” in the Anti-spam section, you notice a URL that points to your email server. By default it points to port 16372 on the email server. This is the first clue that gives you an idea that this is potentially a problem with the firewall on the email server:
In the firewall settings on the email server, allow the “Domain” network access to the “Trend Micro Messaging Security Agent” by checking the appropriate checkbox as shown in the image below:
You should now be able to configure the email server specific settings from within the Trend Worry Free Business Security console.