When attempting to open “Server Configuration>Client Access” from the Exchange Management Console, you receive the following error: _An IIS directory entry couldn’t be created. The error message is Access is denied. HResult = -2147024891 It was running the command ‘Get-OwaVirtualDirectory’.
Running the command listed in the error in the Exchange Management Shell gives you some additional information:
To resolve this issue, add the “domainExchange Trusted Subsystem” group to the local administrators group of all of your exchange servers_._